ZFP36 Monoclonal Antibody (OTI1A2)
Supplier Thermo fisher
$554.02
/ 100 ul
Target Information
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
- Protein names mRNA decay activator protein ZFP36
- Protein alternative names Growth factor-inducible nuclear protein NUP475, TPA-induced sequence 11, Tristetraprolin, Zinc finger protein 36, , G0/G1 switch regulatory protein 24, Growth factor-inducible nuclear protein NUP475, Tristetraprolin, Zinc finger protein 36,
- Immunogen Full length human recombinant protein of ZFP36 produced in HEK293T cell
- Conjugate/tag Unconjugated
- Antibody type Primary Antibody
- Catalog Number MA5-25406
- Isotype IgG2a
- Storage format PBS, pH 7.3, with 1% BSA, 50% glycerol
- Clonality Monoclonal
- Accession numbers P26651 P22893
- Gene target ZFP36
- Clone OTI1A2
- Datasheet https://www.thermofisher.com/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=MA5-25406&version=302
