Origene

VEGFA Rabbit Monoclonal Antibody [Clone ID: R04-6D7]

Supplier Origene

$413.25 / 100 ul
Applications : Western Blot
Reactivity : Mouse / Human / Rat
Conjugate/Tag : Unconjugated
Host: : Rabbit

Swiss-Prot Acc.P15692.Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development .

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