SIRT1 Monoclonal Antibody (OTI1H1)
Supplier Thermo fisher
$550.28
/ 100 ul
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
- Protein names NAD-dependent protein deacetylase sirtuin-1
- Protein alternative names NAD-dependent protein deacylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, SIR2alpha, , NAD-dependent protein deacylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, ,
- Immunogen Human recombinant protein fragment corresponding to amino acids 552-676 of SIRT1 produced in E.coli
- Conjugate/tag Unconjugated
- Antibody type Primary Antibody
- Catalog Number MA5-27216
- Isotype IgG1
- Storage format PBS, pH 7.3, with 1% BSA, 50% glycerol
- Clonality Monoclonal
- Accession numbers Q96EB6 Q923E4
- Gene target SIRT1
- Clone OTI1H1
- Datasheet https://www.thermofisher.com/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=MA5-27216&version=302
