SC35 (SRSF2) Rabbit Monoclonal Antibody [Clone ID: R04-7J2]

Supplier Origene

$411.69 / 100 ul
Applications : Western Blot / Immunoprecipitation / Immunohistochemistry
Reactivity : Human / Rat
Conjugate/Tag : Unconjugated
Host: : Rabbit

Swiss-Prot Acc.Q01130.Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.

  • Protein names Serine/arginine-rich splicing factor 2
  • Protein alternative names Protein PR264, Splicing component, 35 kDa, Splicing factor SC35, Splicing factor, arginine/serine-rich 2,
  • Conjugate/tag Unconjugated
  • Catalog Number TA385322
  • Isotype IgG
  • Storage format 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
  • Clonality Monoclonal
  • Accession numbers Q01130
  • Clone R04
  • Datasheet https://cdn.origene.com/datasheet/ta385322.pdf
  • MSDS https://cdn.origene.com/sds/ta385322.pdf
  • Shipping handling time 28 days

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