S100A12 Monoclonal Antibody (OTI1D1)
Supplier Thermo fisher
$547.05
/ 100 ul
Target Information
S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
- Protein names Protein S100-A12
- Protein alternative names CGRP, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, Extracellular newly identified RAGE-binding protein, Migration inhibitory factor-related protein 6
- Immunogen Full length human recombinant protein of S100A12 produced in HEK293T cell
- Conjugate/tag Unconjugated
- Antibody type Primary Antibody
- Catalog Number MA5-25436
- Isotype IgG1
- Storage format PBS, pH 7.3, with 1% BSA, 50% glycerol
- Clonality Monoclonal
- Accession numbers P80511
- Gene target S100A12
- Clone OTI1D1
- Datasheet https://www.thermofisher.com/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=MA5-25436&version=316
