ROCK2 (Rho-associated Protein Kinase 2, Rho Kinase 2, Rho-associated, Coiled-coil-containing Protein Kinase 2, p164 ROCK-2, KIAA0619)

Supplier US Biological

$548.00 / 100 ug
Applications : Western Blot / Immunofluorescence
Reactivity : Human
Host: : Mouse

Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase,which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388aa residues with a calculated molecular mass of approximately 161kD. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al. (2003) concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.||Applications:|Suitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested.||Recommended Dilution:|Immunofluorescence: 10ug/ml|Optimal dilutions to be determined by the researcher.||AA Sequence:|KPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

  • Immunogen Partial recombinant corresponding to aa1279-1388 from ROCK2 (NP_004841) with GST tag. MW of the GST tag alone is 26kD.
  • Antibody type Primary Antibody
  • Catalog Number 132721
  • Storage format Supplied as a liquid in PBS, pH 7.2.
  • Clonality Monoclonal
  • Clone 2A4
  • Datasheet

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