PTP1B Monoclonal Antibody (OTI1A2)

Supplier Thermo fisher

$560.59 / 100 ul
Applications : Western Blot / Flow Cytometry / Immunocytochemistry
Reactivity : Human
Conjugate/Tag : Unconjugated
Host: : Mouse

Target Information

PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

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