p65 Antibody / NF-kB (R30754)

Supplier NSJ Bioreagents

$419.00 / 100 ug
Applications : Western Blot / Immunofluorescence / Immunohistochemistry / Immunocytochemistry
Reactivity : Rat / Mouse / Human
Host: : Rabbit

RELA, also called NFKB3 or NFKB, p65 subunit is part of the NF-kB complex. The complex is inhibited by I-kappa-B proteins, which inactivates NFkB by trapping it in the cytoplasm. The p65 heterodimer is the most abundant form of NF-kB. It is a nonhistone substrate of HDAC3 and that IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes for subsequent NF-kB responses. Its nucleocytoplasmic redistribution coincided with export of PPARG, and immunoprecipitation analysis indicated that PPARG-RELA association was dependent on the PPARG C-terminal ligand-binding domain. IKK-dependent phosphorylation of RELA on Ser468 enhanced binding of GCN5 to RELA and its ubiquitination.

  • Protein names Transcription factor p65
  • Protein alternative names Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, , ,
  • Immunogen An amino acid sequence from the middle region of the human protein (VPIEEQRGDYDLNAVR) was used as the immunogen for this p65 antibody (100% homologous in human, mouse and rat).
  • Antibody type Primary Antibody
  • Catalog Number R30754
  • Isotype Ig
  • Storage format Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
  • Clonality Polyclonal
  • Accession numbers Q04206
  • Gene target RELA
  • Shipping handling time 1 days

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