p53 Antibody / TP53 [clone TP53/2719] (V8129)

Supplier NSJ Bioreagents

$499.00 / 100 ug
$219.00 / 20 ug
$499.00 / 100 ug
Applications : Immunohistochemistry
Reactivity : Human
Host: : Mouse

The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

  • Immunogen Human recombinant protein was used as the immunogen for this p53 antibody.
  • Antibody type Primary Antibody
  • Catalog Number V8129-100UG
  • Isotype IgG2b kappa
  • Clonality Monoclonal
  • Shipping handling time 1 days

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