MIB1 Rabbit Monoclonal Antibody [Clone ID: R06-3D9]

Supplier Origene

$417.43 / 100 ul
Applications : Western Blot
Reactivity : Mouse / Human
Conjugate/Tag : Unconjugated
Host: : Rabbit

Swiss-Prot Acc.Q86YT6.E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

  • Protein names E3 ubiquitin-protein ligase MIB1
  • Protein alternative names DAPK-interacting protein 1, Mind bomb homolog 1, RING-type E3 ubiquitin transferase MIB1, Zinc finger ZZ type with ankyrin repeat domain protein 2,
  • Conjugate/tag Unconjugated
  • Catalog Number TA384779
  • Isotype IgG
  • Storage format 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
  • Clonality Monoclonal
  • Accession numbers Q86YT6
  • Gene target MIB1
  • Clone R06
  • Datasheet https://cdn.origene.com/datasheet/ta384779.pdf
  • MSDS https://cdn.origene.com/sds/ta384779.pdf
  • Shipping handling time 28 days

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