MAP2K2 Monoclonal Antibody (OTI1A2), TrueMAB™

Supplier Thermo fisher

$453.29 / 100 ul
Applications : Western Blot / Immunohistochemistry / Immunocytochemistry
Reactivity : Rat / Dog / Mouse / Human
Conjugate/Tag : Unconjugated
Host: : Mouse

Target Information

MEK1 (Mitogen activated protein kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

  • Protein names Dual specificity mitogen-activated protein kinase kinase 2
  • Protein alternative names ERK activator kinase 2, MAPK/ERK kinase 2, , ,
  • Immunogen Full length human recombinant protein of human MAP2K2 produced in HEK293T cell.
  • Conjugate/tag Unconjugated
  • Antibody type Primary Antibody
  • Catalog Number TA505680
  • Isotype IgG2a
  • Storage format PBS with 1% BSA, 50% glycerol
  • Clonality Monoclonal
  • Accession numbers Q1HG70 P36507 P36506 Q63932
  • Gene target MAP2K2
  • Clone OTI1A2
  • Datasheet

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