ITGB6 Rabbit Monoclonal Antibody [Clone ID: R04-6E9]
Supplier Origene
$416.06
/ 100 ul
Swiss-Prot Acc.P18564.Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
- Protein names Integrin beta-6
- Protein alternative names , , , ,
- Conjugate/tag Unconjugated
- Catalog Number TA384566
- Isotype IgG
- Storage format 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Clonality Monoclonal
- Accession numbers P18564
- Clone R04
- Datasheet https://cdn.origene.com/datasheet/ta384566.pdf
- MSDS https://cdn.origene.com/sds/ta384566.pdf
- Shipping handling time 28 days
