IFIT3 Monoclonal Antibody (OTI1G1), TrueMAB™

Supplier Thermo fisher

$450.23 / 100 ul
Applications : Western Blot / Flow Cytometry / Immunocytochemistry
Reactivity : Human
Conjugate/Tag : Unconjugated
Host: : Mouse

Target Information

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

  • Protein names Interferon-induced protein with tetratricopeptide repeats 3
  • Protein alternative names CIG49, ISG-60, Interferon-induced 60 kDa protein, Interferon-induced protein with tetratricopeptide repeats 4, Retinoic acid-induced gene G protein
  • Immunogen Full length human recombinant protein of human IFIT3 produced in HEK293T cell.
  • Conjugate/tag Unconjugated
  • Antibody type Primary Antibody
  • Catalog Number TA500726
  • Isotype IgG1
  • Storage format PBS with 1% BSA, 50% glycerol
  • Clonality Monoclonal
  • Accession numbers O14879
  • Gene target IFIT3
  • Clone OTI1G1
  • Datasheet https://cdn.origene.com/datasheet/ta500726.pdf

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