Histone H3 polyclonal antibody

Supplier Bioworld

$158.00 / 50 ul
$275.00 / 100 ul
Applications : Immunofluorescence / Western Blot / Immunohistochemistry
Reactivity : Mouse / Rat / Human
Conjugate/Tag : Unconjugated
Host: : Rabbit

In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of histones H2A, H2B, H3 and H4, and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. p300 preferentially acetylates Histone H3 at lysines 14 and 18 and Histone H4 at lysines 5 and 8. PCAF in its native form, primarily acetylates Histone H3 at lysine 14 to a monoacetylated form, and less efficiently acetylates Histone H4 at lysine 8. Histone H4 may also be acetylated at lysines 12 and 16, and the involvement of acetylated H4 with Histones H2A, H2B and H3 suggests that acetylated histones may be involved in dynamic chromatin remodeling.

  • Protein names Histone H3.1, Histone H3.3, Histone H3.2
  • Protein alternative names Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, , , , , , H3-clustered histone 13, H3-clustered histone 14, H3-clustered histone 15, Histone H3/m, Histone H3/o
  • Immunogen Synthetic peptide, corresponding to Human Histone H3.
  • Conjugate/tag Unconjugated
  • Antibody type Primary Antibody
  • Catalog Number BS69002
  • Isotype IgG
  • Clonality Polyclonal
  • Accession numbers P68431 Q71DI3 P84243
  • Gene target H31
  • Datasheet http://www.bioworlde.com/pdf/BS69002.pdf
  • MSDS http://www.bioworlde.com/MSDS/MSDS.pdf

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