ERBB2 polyclonal antibody

Supplier Bioworld

$158.00 / 50 ul
$275.00 / 100 ul
Applications : Western Blot
Reactivity : Human
Conjugate/Tag : Unconjugated
Host: : Rabbit

The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway.

  • Protein names Receptor tyrosine-protein kinase erbB-2
  • Protein alternative names Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2
  • Immunogen Synthetic peptide, corresponding to Human ERBB2.
  • Conjugate/tag Unconjugated
  • Antibody type Primary Antibody
  • Catalog Number BS1170
  • Isotype IgG
  • Clonality Polyclonal
  • Accession numbers P04626
  • Gene target ERBB2
  • Datasheet http://www.bioworlde.com/pdf/BS1170.pdf
  • MSDS http://www.bioworlde.com/MSDS/MSDS.pdf

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