CYP2A6 Monoclonal Antibody (OTI1D2)
Supplier Thermo fisher
$540.49
/ 100 ul
Target Information
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
- Protein names Cytochrome P450 2A6
- Protein alternative names 1,4-cineole 2-exo-monooxygenase, CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 IIA3, Cytochrome P450(I)
- Immunogen Full length human recombinant protein of CYP2A6 produced in HEK293T cell
- Conjugate/tag Unconjugated
- Antibody type Primary Antibody
- Catalog Number MA5-25758
- Isotype IgG2b
- Storage format PBS, pH 7.3, with 1% BSA, 50% glycerol
- Clonality Monoclonal
- Accession numbers P11509
- Gene target CYP2A6
- Clone OTI1D2
- Datasheet https://www.thermofisher.com/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=MA5-25758&version=316
