CD44 Mouse monoclonal antibody

Supplier Bioworld

$258.00 / 50 ul
$398.00 / 100 ul
Applications : Western Blot / Flow Cytometry / Immunohistochemistry
Reactivity : Human
Conjugate/Tag : Unconjugated
Host: : Mouse

CD44 is a type I transmembrane glycoprotein that mediates cell-cell and cell-matrix interaction through its affinity for hyaluronic acid (HA) and possibly through other parts of the extracellular matrix (ECM). CD44 is highly polymorphic, possesses a number of alternative splice variants and undergoes extensive post-translational modifications. Increased surface levels of CD44 are characteristic of T cell activation, and expression of the protein is upregulated during the inflammatory response. Interactions between CD44 and HER2 have been linked to an increase in ovarian carcinoma cell growth. CD44 interacts with ezrin, radixin and moesin (ERM), linking the actin cytoskeleton to the plasma membrane and the ECM. CD44 is constitutively phosphorylated at Ser325 in resting cells. Activation of PKC results in phosphorylation of Ser291, dephosphorylation of Ser325, disassociation of ezrin from CD44, and directional motility.

  • Protein names CD44 antigen
  • Protein alternative names CDw44, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I
  • Immunogen This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of CD44.
  • Conjugate/tag Unconjugated
  • Antibody type Primary Antibody
  • Catalog Number MB9004
  • Isotype IgM
  • Clonality Monoclonal
  • Accession numbers P16070
  • Gene target CD44
  • Datasheet
  • MSDS

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