CD3e monoclonal antibody

Supplier Bioworld

$158.00 / 50 ul
$275.00 / 100 ul
Applications : Western Blot / Immunohistochemistry
Reactivity : Human
Conjugate/Tag : Unconjugated
Host: : Mouse

When T cells encounter antigens via the T cell receptor (TCR), information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery . This activation process depends mainly on CD3 (Cluster of Differentiation 3), a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: ζ, γ, ε, and δ. Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif (ITAM) . Engagement of the TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and the p85 subunit of PI-3 kinase . TCR ligation also induces a conformational change in CD3ε, such that a proline region is exposed and then associates with the adaptor protein Nck .

  • Protein names T-cell surface glycoprotein CD3 epsilon chain
  • Protein alternative names T-cell surface antigen T3/Leu-4 epsilon chain, , , ,
  • Immunogen KLH-conjugated synthetic peptide encompassing a sequence within human CD3e. The exact sequence is proprietary.
  • Conjugate/tag Unconjugated
  • Antibody type Primary Antibody
  • Catalog Number MB66179
  • Clonality Monoclonal
  • Accession numbers P07766
  • Gene target CD3E
  • Datasheet
  • MSDS

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