APPBP1 (NAE1) Rabbit Monoclonal Antibody [Clone ID: R03-1A7]
Supplier Origene
$413.25
/ 100 ul
Applications
:
Western Blot
/
Immunoprecipitation
Reactivity
:
Human
Conjugate/Tag
:
Unconjugated
Host:
:
Rabbit
Swiss-Prot Acc.Q13564.Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
- Protein names NEDD8-activating enzyme E1 regulatory subunit
- Protein alternative names Amyloid beta precursor protein-binding protein 1, 59 kDa, Amyloid protein-binding protein 1, Proto-oncogene protein 1, ,
- Conjugate/tag Unconjugated
- Catalog Number TA384833
- Isotype IgG
- Storage format 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Clonality Monoclonal
- Accession numbers Q13564
- Gene target NAE1
- Clone R03
- Datasheet https://cdn.origene.com/datasheet/ta384833.pdf
- MSDS https://cdn.origene.com/sds/ta384833.pdf
- Shipping handling time 28 days
