Anti-CD3e (Hu) from Mouse – unconj.

Supplier Dianova

$393.26 / 100 ul
Applications : ELISA / Western Blot / Flow Cytometry
Reactivity : Human
Conjugate/Tag : unconjugated
Host: : Mouse

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
CD3E antibody detects endogenous levels of total CD3E.

  • Protein names T-cell surface glycoprotein CD3 epsilon chain
  • Protein alternative names T-cell surface antigen T3/Leu-4 epsilon chain, , , ,
  • Conjugate/tag unconjugated
  • Antibody type Primary Antibody
  • Catalog Number BF0191-01
  • Isotype IgG1
  • Clonality Monoclonal
  • Accession numbers P07766
  • Gene target CD3E
  • Datasheet

More information about Dianova

Show all CD3E antibodies

Show all products from Dianova

Similar antibodies