All TP53 Cellular tumor antigen p53 antibodies

The tumor suppressor gene TP53 is the most commonly mutated gene in various cancers. A recent research published in Science by Hsiue et al. introduced a CD3-targeting bispecific antibody that can bind to tumor cells by recognizing mutation-associated neoantigens and activate T cell-mediated tumor killing by binding to CD3. The research developed an antibody-based therapeutic approach that targets a neoantigen derived from a common TP53 mutation in a highly specific fashion. It effectively activated T cells and lysed tumor cells both in vitro and in vivo despite the low antigen density on their surface.

Showing 73 - 96 of 3866 results