All PECAM1 Platelet endothelial cell adhesion molecule antibodies
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is a protein that plays a key role in removing aged neutrophils from the body. It is also known as cluster of differentiation 31 (CD31) and is encoded by the PECAM1 gene found on chromosome17q23.3. PECAM-1 is a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules with six Ig-like domains. It has a range of functions, notably its contributions to leukocyte extravasation during inflammation and in maintaining vascular endothelial integrity.
PECAM-1 (platelet endothelial cell adhesion molecule 1) is a 130 kDa member of the immunoglobulin (Ig) gene superfamily that is expressed on the surfaces of platelets and leukocytes and concentrated at the intercellular junctions of confluent endothelial cell monolayers. PECAM-1 is a multi-functional molecule in inflammation and vascular biology. It is expressed on all cells within the vascular compartment, being expressed to different degrees on most leukocyte sub-types, platelets, and on endothelial cells where its expression is largely concentrated at junctions between adjacent cells.
PECAM-1 has been shown to be involved in various biological processes such as leukocyte transmigration, angiogenesis, thrombosis, and immune regulation. It has been suggested that PECAM-1 may play a role in the pathogenesis of various diseases such as cancer, cardiovascular disease, and autoimmune disorders.
In summary, PECAM-1 is an important protein that plays a key role in removing aged neutrophils from the body. It has a range of functions including its contributions to leukocyte extravasation during inflammation and in maintaining vascular endothelial integrity. PECAM-1 has been shown to be involved in various biological processes such as leukocyte transmigration, angiogenesis, thrombosis, and immune regulation. It may also play a role in the pathogenesis of various diseases such as cancer, cardiovascular disease, and autoimmune disorders.
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