All ESR1 Estrogen receptor antibodies
The Estrogen receptor (ER) is a protein that binds to estrogen and plays a crucial role in the development and progression of breast cancer. The ER is encoded by the ESR1 gene. The ESR1 gene is located on chromosome 6q25.1 and consists of eight exons. The ER is a transcription factor that regulates the expression of genes involved in cell proliferation, differentiation, and apoptosis.
Antibodies targeting the ER are used in research to study the role of the ER in breast cancer. These antibodies are used to detect the presence of the ER in breast cancer cells and to determine the level of expression of the ER. Antibodies targeting the ER are also used to study the interaction between the ER and other proteins involved in breast cancer development and progression.
The ESR1 gene is frequently mutated in breast cancer. Mutations in the ESR1 gene can lead to resistance to endocrine therapy, which is a common treatment for breast cancer. Endocrine therapy works by blocking the action of estrogen on breast cancer cells. However, mutations in the ESR1 gene can lead to resistance to endocrine therapy by altering the structure of the ER protein so that it can still function even in the absence of estrogen.
In conclusion, antibodies targeting ESR1/Estrogen receptor are used in research to study the role of estrogen receptor in breast cancer. The ESR1 gene is frequently mutated in breast cancer which can lead to resistance to endocrine therapy.
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