All ERBB2 Receptor tyrosine-protein kinase erbB-2 antibodies
ERBB2 is a protein that is also known as HER2 (human epidermal growth factor receptor 2). It is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 is overexpressed in many types of cancer, including breast cancer, ovarian cancer, and gastric cancer. It is also associated with poor prognosis in these cancers.
ERBB2 has been identified as a therapeutic target for breast cancer therapy. Experimental studies have revealed that ERBB2 shows many features of a therapeutic target: ERBB2 is able to confer many of the characteristics of a cancerous cell, including uncontrolled proliferation, resistance to apoptosis and increased motility; ERBB2 overexpression is specific to tumor cells; as a cell surface-associated protein, it is easily accessible to drugs and as a kinase it is amenable to targeted inhibition by small molecules.
Trastuzumab (Herceptin) is an antibody that targets ERBB2 and has been approved for the treatment of breast cancer. It binds to the extracellular domain of ERBB2 and inhibits its activity. Lapatinib (Tykerb) is another drug that targets ERBB2. It inhibits both ERBB2 and EGFR activity.
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